Residual oil fly ash worsens pulmonary hyperreactivity in chronic allergic mice
نویسندگان
چکیده
منابع مشابه
Residual oil fly ash worsens pulmonary hyperreactivity in chronic allergic mice
BALB/c mice received saline (SAL groups) or ovalbumin (OVA groups) intraperitoneally (days 1, 3, 5, 7, 9, 11 and 13). After 27 days, a burst of intratracheal OVA or SAL (days 40, 43 and 46) was performed. Animals were then divided into four groups (N=8, each) and intranasally instilled with saline (SAL-SAL and OVA-SAL) or residual oil fly ash (SAL-ROFA and OVA-ROFA). 24h later, total, initial a...
متن کاملTime course of pulmonary burden in mice exposed to residual oil fly ash
Residual oil fly ash (ROFA) is a common pollutant in areas where oil is burned. This particulate matter (PM) with a broad distribution of particle diameters can be inhaled by human beings and putatively damage their respiratory system. Although some studies deal with cultured cells, animals, and even epidemiological issues, so far a comprehensive analysis of respiratory outcomes as a function o...
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Epidemiologic studies have demonstrated increased human morbidity and mortality with elevations in the concentration of ambient air particulate matter (PM). Fugitive fly ash from the combustion of oil and residual fuel oil significantly contributes to the ambient air particle burden. Residual oil fly ash (ROFA) is remarkable in the capacity to provoke injury in experimental systems. The unique ...
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Exposure of animals to airborne particulates is associated with pulmonary injury and inflammation. In the studies described here, primary cultures of rat tracheal epithelial (RTE) cells were exposed to suspensions of residual oil fly ash (ROFA). ROFA exposure resulted in progressive cytotoxicity whereby the amount of lactate dehydrogenase (LDH) released was significantly greater at 24 h than at...
متن کاملPhysical and biological studies of coal and oil fly ash.
Studies were performed to compare the physical and chemical characteristics and the in vitro macrophage cytotoxicity of oil and coal fly ash. Sampling methodology was developed to collect size-fractionated particulate matter from the smokestack of either a coal-fired or an oil-fired power plant. Morphological studies demonstrated particle heterogeneity, although most coal fly ash particles appe...
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2011
ISSN: 1569-9048
DOI: 10.1016/j.resp.2011.07.011